| 5 Nov | Delta St 71 | at | Southern Miss 90 | vs ND1 | ||
| 9 Nov | Southern Miss 69 | at | South Alabama 75 | at SBC | ||
| 14 Nov | Southern Miss 63 | at | North Florida 66 | at ASUN | ||
| 19 Nov | Southern Miss 45 | at | Iowa St 73 | at B12 | ||
| 24 Nov | Wm Carey 64 | at | Southern Miss 83 | vs ND1 | ||
| 27 Nov | Gonzaga 94 | vs | Southern Miss 69 | Nassau, Bahamas | vs WCC | |
| 28 Nov | Seton Hall 81 | vs | Southern Miss 56 | Nassau, Bahamas | vs BE | |
| 29 Nov | Alabama 83 | vs | Southern Miss 68 | Nassau, Bahamas | vs SEC | |
| 4 Dec | Tulane 61 | at | Southern Miss 56 | vs AAC | ||
| 7 Dec | S Illinois 69 | at | Southern Miss 72 | vs MVC | ||
| 14 Dec | North Florida 72 | at | Southern Miss 69 | vs ASUN | ||
| 16 Dec | Southern Miss 65 | at | Texas Tech 71 | at B12 | ||
| 21 Dec | Tougaloo 77 | at | Southern Miss 96 | vs ND1 | ||
| 30 Dec | Louisiana Tech 80 | at | Southern Miss 49 | |||
| 4 Jan | Southern Miss 50 | at | Louisiana Tech 78 | |||
| 9 Jan | Southern Miss 64 | at | UTEP 76 | |||
| 11 Jan | Southern Miss 70 | at | UT San Antonio 80 | |||
| 16 Jan | North Texas 72 | at | Southern Miss 52 | |||
| 18 Jan | Rice | at | Southern Miss | |||
| 23 Jan | Southern Miss | at | UAB | |||
| 25 Jan | Southern Miss | at | MTSU | |||
| 30 Jan | Old Dominion | at | Southern Miss | |||
| 1 Feb | Charlotte | at | Southern Miss | |||
| 6 Feb | Southern Miss | at | Marshall | |||
| 8 Feb | Southern Miss | at | WKU | |||
| 13 Feb | FL Atlantic | at | Southern Miss | |||
| 15 Feb | Florida Intl | at | Southern Miss |
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